COVID-19 Critical Intelligence Unit Updates

Evidence Digests

2023

April

Paxlovid, obesity and COVID-19 mortality correlations, COVID-19 detection from wearables

March

Risk factors for post-COVID-19 conditions, COVID-19 vaccine fatigue, COVID-19 pandemic policies, drugs to prevent COVID-19

Thromboprophylaxis after COVID-19 hospitalisation, SARS-CoV-2 effect on respiratory features and mortality, surveillance testing in nursing homes

Mental health symptoms before and during COVID-19, long-term COVID-19 booster effectiveness, BA.4/BA.5 Omicron lineages and immune escape

Thromboembolism risk with hormonal contraception, COVID-19 in children, using EMR to identify long COVID

Remdesivir, the Outbreak.info research platform, telehealth outpatient palliative care, orthostatic tachycardia after COVID-19

February

Past SARS-CoV-2 infection as protection against re-infection, comorbidities, multimorbidity and COVID-19, AI for SARS-CoV-2 variants

Long-term effectiveness of COVID-19 vaccines, bradycardia after remdesivir, COVID-19 knowledge gaps and research priorities

Mortality risk in COVID-19 patients, early treatment with pegylated interferon lambda, ATAGI 2023 booster advice

mRNA vaccines in children aged 5-11 years, pregnancy outcomes, changes in COVID-19 symptoms

January

Long COVID review, Long COVID outcomes at 1 year, bivalent boosters, variants BQ1.1 and XBB.1

COVID-19 vaccinations in pregnancy and haematological malignancy patients, surgery after COVID-19, risk assessment of XBB.1.5

2022

December

COVID-19 and excess mortality, inflammatory bowel disease and COVID-19 outcomes, Omicron BQ.1 and XBB

COVID-19 vaccine effectiveness to prevent post-COVID-19 conditions, FXR inhibition for infection protection, antivirals vs BQ.1.1 and XBB

Reinfection risk, post-COVID-19 syndrome in children and adolescents, medical masks vs N95 respirators for healthcare workers

November

Diabetes risk after COVID-19, angiotensin receptor blockers for COVID-19 treatment, bivalent vaccines

Sequelae associated with reinfection, cardiac function and long COVID, VTE in ischaemic stroke patients with and without COVID-19

Vitamin D3 in ICU COVID-19 patients, cognitive deficits in long COVID, knowledge mobilisation, Evusheld for immunocompromised patients

Cardiovascular outcomes in unvaccinated COVID-19 survivors, mental healthcare after COVID-19, WHO statement on Omicron BQ.1 and XBB

October

Molnupiravir in early SARS-CoV-2 infection, AI applications in COVID-19 clinical response, cardiovascular disease after COVID-19 infection

Cardiopulmonary exercise testing to evaluate long COVID, long COVID conditions, key lessons from Australia’s public health response

ECMO, real world effectiveness of antivirals, molnupiravir trial, multilateralism lessons and innovations from COVID-19

Peripartum outcomes and COVID-19 vaccination, how COVID-19 shaped mental health, long-term neurological sequelae of SARS-CoV-2 infection

September

COVID-19 and major arterial and venous thrombotic diseases, long-term neurologic outcomes of COVID-19, “twindemic” of influenza and COVID-19

Lessons for the future from the COVID-19 pandemic, COVID-19 patterns, prevalence and risk factors for long COVID after mild disease

Global acceptance and uptake of COVID-19 vaccination, COVID-19 and children, scientific advice in COVID-19 policy, WHO says end is in sight

Post-acute SARS-CoV-2 infection outcomes in children, Paxlovid, Omicron-specific boosters

Immune responses to COVID-19 vaccines, aerosol generating procedures, real world effectiveness of oral antivirals

August

COVID-19 incubation period, physical activity and COVID-19 risk, long COVID in children and adolescents, Paxlovid studies

SARS-CoV-2 infection in children, brain infection in COVID-19, virological characteristics of Omicron BA.2.75, COVID rebound

COVID-19 vaccination in pregnancy, SARS-CoV-2 hybrid immunity, rebound infection following Paxlovid treatment

Baricitinib, long COVID and disability, effectiveness of monoclonals and antivirals on subvariants

July

Smell and taste dysfunction in COVID-19 patients, nasal vaccines, preventive medication for COVID-19 infection

Drug treatments for COVID-19, endemic paediatric viral illnesses after COVID-19 disruption, duration of shedding of culturable Omicron

Short-term safety of COVID-19 vaccines in Australia, clinical prediction models for mortality, effectiveness of vaccine mandates

Antibody evasion by Omicron subvariants, immunity and infectivity in COVID-19, ATAGI recommendation for a winter dose

Long distance airborne transmission of SARS-CoV-2, people in intensive care with COVID-19 in Australia, vaccination and long COVID

June

Paxlovid and hospitalisations, continuing COVID-19 waves, risk of long COVID with Delta and Omicron, mRNA vaccines for under-5s

Telerehabilitation post-discharge, effects of previous infection & vaccination on Omicron infection, research questions on long COVID

Long term physical and mental sequelae of COVID-19, tixagevimab–cilgavimab for prevention, natural and hybrid immunity to SARS-CoV-2

COVID-19 in pregnancy, adapting vaccines in the changing face of SARS-CoV-2, Evusheld for preventing COVID-19 during Omicron

May

COVID-19 sequelae and immunity, long COVID, Omicron BA.4 and BA.5, variant specific symptoms

Long COVID symptoms after COVID-19 vaccination, immune escape by Omicron variants, reinfections

Phase 3 trial of Comirnaty (Pfizer) third dose, unexplained post-acute infection syndromes, first COVID-19 Breathalyzer

Immune response in COVID-19, changes in smell and taste perception, the role of community leaders during the pandemic in Australia

Intracellular overdrive for SARS-CoV-2, T cell defence against COVID-19, generating evidence during a pandemic

Prone positioning and endotracheal intubation, impact of leadership on the nursing workforce, prevalence of post-intensive care syndrome

Human-to-dog SARS-CoV-2 transmission, COVID-19 pre-symptomatic detection using a smartwatch, zero COVID strategy in China

Spikevax (Moderna) in children aged 6 to 11 years, two-year health outcomes in hospitalised COVID-19 patients, coronavirus ‘ghosts’

Mortality among patients with cancer and SARS-CoV-2, fourth-dose mRNA vaccine boosters, efficacy of monoclonal antibodies against Omicron

Mortality among patients with cancer and SARS-CoV-2, fourth-dose mRNA vaccine boosters, efficacy of monoclonal antibodies against Omicron

Psychotropic medications and risk of COVID-19, tackling endoscopy backlogs due to COVID, UK updates on variants and long COVID

Built environment and aerosol contamination, third dose vaccines vs Delta and Omicron, sensitivity of omicron subvariants to monoclonal antibodies

New COVID-19 vaccines, convalescent plasma for early outpatient treatment, ECMO for acute COVID-19 respiratory failure

Remdesivir for hospitalised COVID-19 patients, Omicron BA.4 and BA.5 lineages, BA.2.12.1

Human genetic epidemiology of COVID-19, pathophysiology of COVID-19 ARDS and MIS-C in children, mRNA vaccine effectiveness over time

Home antigen testing over the course of SARS-CoV-2 infection, impact of the pandemic on general practice in Australia, Omicron BA.4 and BA.5

Household secondary SARS-CoV-2 attack rates, glycaemic control and breakthrough infections, smart lockdowns to control COVID-19

April

Online breathing and wellbeing program for persistent COVID symptoms, symptom burden questionnaire for long COVID, parosmia practice points

COVID-19 in pregnancy, digital health innovations for non-communicable disease management, online misinformation and vaccine hesitancy

Infection induced and vaccine-induced immunity, second booster in adults aged 60+ years, chilblains and COVID-19 diagnoses in Victoria

Evusheld for COVID-19 prevention, awake prone positioning, outcomes associated with non-invasive ventilation, high-flow oxygen and CPAP

COVID-19 and kidney disease, fourth dose of Pfizer, protection following booster in adolescents, changes in life expectancy between 2019 & 2020

COVID-19 vaccines in solid organ transplant recipients, oral famotidine, estimating disease severity of Omicron and Delta infections

Myopericarditis after vaccination, long COVID occurrence, BA.1 and BA.2 immune response in naïve and prior infected persons

Global, regional and national daily and cumulative SARS-CoV-2 infections, COVID-19 vaccine waning and the effectiveness of boosters, BA.4 and BA.5

Budenoside, differences between Omicron and Delta infections, thromboembolism and bleeding after COVID-19

Fluvoxamine for outpatients, COVID-19 and stroke treatment response times, sotrovimab resistance in immunocompromised COVID-19 patients

Fourth dose of Comirnaty (Pfizer) against Omicron, the course of Long COVID, dynamics and scale of the Omicron epidemic in England

COVID-19 and risk factors in cancer patients, cardiac impairment in Long COVID, Omicron infections in triple vaccinated individuals

The COVID Positive Pathway in Melbourne, non-pharmacological interventions, preparing for the next COVID-19 viral variant

Phase 3 trial of a DNA vaccine, risk of reinfection and hospitalisation with natural and hybrid immunity, human challenge trial, influenza under COVID

Early ivermectin treatment, ruxolitinib, SARS-CoV-2 pathogenesis, Pfizer vaccine protection against Omicron in children and adolescents

March

SARS-CoV-2 reinfections in children, hydration of the nose, larynx, and trachea to reduce COVID-19 symptoms, a global epidemiological database

TMPRSS2 inhibitor, global genomic surveillance, corticosteroid monotherapy in multisystem inflammatory syndrome in children

Parenchymal lung abnormalities, tocilizumab plus dexamethasone vs dexamethasone, SARS-CoV-2 entry into cells, vaccine vs Omicron BA.2

Awake prone positioning, COVID-19 vaccination in pregnancy, early aspirin use and mortality, ATAGI recommendations for second booster

The safety and efficacy of a third does of Comirnaty (Pfizer), incident diabetes in long COVID, viral load dynamics of Delta and Omicron

Antiplatelet therapy, perinatal complications associated with SARS-CoV-2 infection during pregnancy, COVID-19 pneumonitis in children

Comirnaty and Vaxzevria in people over 50, anticoagulation in patients with atrial fibrillation and COVID-19, surveillance systems for the new normal

Active immunotherapy in cancer patients with COVID-19, socio-economic factors and incidence, two doses of Comirnaty (Pfizer) in 5-15 year olds

SARS-CoV-2 transmission from mother-to-child, COVID-19 and cardiovascular disease, hospitalisation and death with Omicron and Delta

High-flow oxygen therapy and non-invasive ventilation, losartan treatment for inpatients, neutralisation of Omicron BA.1 and BA.2 variants

Molnupiravir, mechanical thrombectomy for acute ischaemic stroke in COVID-19 patients, acute COVID-19 severity and mental health trajectories

Frailty and mortality risk, pausing methotrexate in older patients with rheumatic disease, antigenic evolution of SARS-CoV-2

Excess mortality due to COVID-19, pulmonary rehabilitation for post-COVID-19, long COVID in children and adolescents

Rapid and laboratory-free COVID-19 triage for emergency care, long COVID symptoms, Omicron stability on various surfaces

Seroconversion in mild COVID-19, resistance in Delta variant following sotrovimab use, recombinant Deltamicron, antivirals vs Omicron BA.2

Dexamethasone post-discharge, cognitive changes in older COVID-19 survivors, self-collected gargle specimen for COVID-19 diagnosis

Tocilizumab, SARS-CoV-2 and changes in brain structure, long COVID evaluation, secondary attack rates of Omicron and Delta in Norway

Waning of viral load reduction post COVID-19 booster, Omicron BA.1 and BA.2 subvariants, co-infection with multiple variants

Vaccines in immunocompromised patients, one-year outcomes post-pneumonia, processes and outcomes in dedicated COVID-19 hospitals

Vaccine effectiveness against Omicron, wearable devices that detect COVID-19, the US COVID-19 preparedness plan

Remdesivir for COVID-19 adults, COVID-19 infection in adults with intellectual disabilities, prescribing nirmatrelvir–ritonavir (PAXLOVID)

Prenatal and neonatal complications of COVID-19, ambulatory monitoring of COVID-19 patients, anticipating the next variant

COVID-19 infection-fatality ratios, COVID-19 and rheumatic disease, waning effectiveness of vaccine third dose, TGA approval for EVUSHIELD

February

Music therapy for hospitalised COVID-19 patients, sudden sensorineural hearing loss after COVID-19 vaccination, RATs for detecting infectiousness

Treatment for COVID-19 or MIS-C in children, implementing digital health for global health security, ATAGI guide on Spikevax (Moderna) for children

Duration of vaccine effectiveness, low-dose radiation therapy, frailty and COVID-19, cholecalciferol (vitamin D3) treatment

Second allergic reaction to COVID-19 vaccines, mortality in cancer patients infected with COVID-19, severity of paediatric hospitalisations in the US

Ivermectin treatment, paediatric hospitalisations and Omicron, risk of SARS-CoV-2 reinfection

Risks of mental health outcomes post-COVID-19, identifying patients at risk of clinical deterioration, TGA approval for SPIKEVAX in people 6+ years old

Oral nirmatrelvir, Comirnaty (Pfizer) effectiveness after COVID-19 recovery, childhood obesity and the risk of SARS-CoV-2 infection

Geriatric risk factors for COVID-19 in adults with cancer, lessons from lived experience of long COVID, co-infection with Omicron and Delta variants

SARS-CoV-2 infection and vaccination in rheumatic and musculoskeletal disease, Australia’s genomics surveillance platform (AusTrakka)

Casirivimab, imdevimab and favipiravir, ATAGI guidance, Omicron sublineages

Molnupiravir phase 3 trial, oral famotidine, Novavax clinical trial, future pandemic preparedness, antibody evasion of Omicron sublineages

Sofosbuvir-based treatment, neutralisation against Omicron from previous non-Omicron infection, long COVID in in adolescents

Long COVID-19 in children, outbreak preparedness in Australian aged care facilities, protection of vaccination and infection against Omicron and Delta

Oral antivirals, maternal outcomes, cardiovascular outcomes, antibodies 16 months post-infection, COVID-19 responses in OECD countries

TGA provisional determination for VEKLURY (remdesivir)

Azithromycin, mRNA vaccines in pregnancy, fact checking and the ‘infodemic’

Antiviral therapies, bromhexine hydrochloride prophylaxis, pandemic preparedness in 177 countries, SARS-CoV-2 human challenge study

Quadrivalent influenza vaccine administered with Spikevax, innate immunity vs SARS-CoV-2, immunology of SAR-CoV-2 infection in children

Consumer interpretation of COVID-19 self-test kits, Omicron BA.1 & BA.2 in household transmission, building an evidence ecosystem

Tocilizumab and corticosteroids, memory B cells after triple vaccination, readmissions and deaths post COVID-19 hospitalisation

January

Remdesivir for outpatients, duration of protection by COVID-19 vaccines, relative infectiousness of breakthrough infections and reinfections

Reinfection risk after SARS-CoV-2, potential indirect impacts of COVID-19 on Australian children, immunoglobulin predictor of post-acute COVID-19

Non-invasive respiratory strategies in COVID-19, high-dose polyclonal intravenous immunoglobulin, curcumin in treating COVID-19

Boosters post-CoronaVac, immunotherapy, physicians seeking outpatient care for mental health and substance use during COVID-19

Neutralising antibodies following CoronaVac and Comirnaty (Pfizer), clinical severity of Omicron, post-acute COVID-19 (long COVID) in Europe

Rapid COVID tests, Omicron and therapeutic monoclonal antibodies, breakthrough infections, Omicron symptoms

Melatonin, P2Y12 inhibitors in non-critical patients, COVID and pregnancy outcomes, mental health service for Australian healthcare workers

Healthcare use by children post-COVID, post-acute neurological consequences of COVID-19, T-cell responses to Omicron

Casirivimab and imdevimab, Comirnaty (Pfizer) booster effectiveness, COVID-19 therapeutics for non-hospitalised patients

COVID-19 in adolescents, indirect impacts of COVID-19 on childhood infections, clinical outcomes in the Omicron wave

Atorvastatin, false-positive RATs, heterologous boosters, TGA provisional determination for EVUSHELD

COVID-19 Monitor - COVID-19 cases, variants, vaccines, hospitalisations and deaths

Reducing self-isolation periods, Omicron breakthrough infections, hospitalisations and vaccine protection

2021

December

Molnupiravir, remdesivir, booster protection, neutralisation and severity of Omicron

Hyperbaric oxygen treatment, Novavax phase 3 trial, the need for updated evidence synthesis, universal COVID-19 vaccines

Asymptomatic SARS-CoV-2 infections, sarilumab, COVID-19 in 2022, boosters and Omicron

High vs standard intensity of thromboprophylaxis, COVID-19 convalescent plasma, reinfections in Australia, pulse oximetry for home monitoring

COVID-19 and anti-TNF treatments, droplet digital PCR, breakthrough infections with Omicron variant despite mRNA booster

Volatile organic compounds-based breath analysis, PPE litter, public health system requirements in Australia

Comirnaty (Pfizer) vaccine booster, post-acute COVID-19, Omicron studies, TGA approval for Spikevax (Moderna) booster

Protection from natural immunity vs vaccination, heterologous vaccination, global response to Omicron, breakthrough infections, Omicron and Pfizer

Anticoagulant regimens, care of older people and people requiring palliative care with COVID-19, healthcare access for young Australians

Randomised controlled trial of seven COVID-19 vaccines as boosters, breakthrough infections, spike proteins on the Omicron and Delta variants

Treatment studies, BMJ series on China’s response to COVID-19, transmission routes, Omicron and reinfection

Baricitinib, predictive scores for pulmonary embolism, asthma and COVID-19 in children, persistent pulmonary pathology

Universal COVID-19 testing in Hong Kong, booster vaccination effectiveness, pulse oximetry remote monitoring

Immunomodulation and thromboembolic risk, BMJ series on COVID-19 preparedness, response and future implications, COVID trends in children

November

Prevention strategy, fungal infections, WHO updates on Omicron

Sustainable futures after COVID-19, effectiveness of Comirnaty and Vaxzevria against household transmission, Omicron variant of concern

Non-pharmaceutical inventions, ‘positive expiratory pressure flute self-care’ in early COVID-19, rapid antigen tests

Subcutaneous interferon-beta, neurological complications of COVID-19, TGA approval for RONAPREVE (casirivimab + imdevimab)

Umifenovir, inhaled ciclesonide for outpatient treatment, long-term sequelae one year after COVID-19 hospitalisation

Novavax co-administered with influenza vaccines, antibody titres before and after mRNA boosters, care models for post-acute COVID-19 syndrome

Public health measures for COVID-19, aspirin in hospitalised COVID-19 patients, leadership development

Mental health concerns during COVID-19, factors associated with waning immunity, booster dose effectiveness

Neutralising antibody titres, lopinavir-ritonavir prophylaxis, automated text messaging service for monitoring COVID-19 at home

SARS-CoV-2 antigen tests, COVID-19 treatment for pregnant women, entering Australia’s third year with COVID-19

Covaxin (BBV152) vaccine, intravenous immunoglobulins, burden of post-acute sequelae of COVID-19

Immunomodulators for COVID-19, deaths in children after SARS-CoV-2 infection in England, the future of SARS-CoV-2 vaccination

Comirnaty (Pfizer) vaccine for children, Spikevax (Moderna) in cancer patients receiving treatment, aerosol generating procedures

Years of life lost to COVID-19, payments for vaccination, news media and risk narratives, vaccine ‘real world’ effectiveness

Molnupiravir, paxlovid, continuous remote monitoring of COVID-19 patients, key epidemiological parameters of COVID-19

COVID-19 rapid diagnostics, aerosol generation from oxygen delivery systems, face mask leakage and facial features, paediatric vaccines

COVID-19 in Victoria, COVID-19 sequelae in cancer patient survivors, breakthrough infections

COVID-19 vaccination in children, immune responses of neonates, elimination vs mitigation strategies

Vaccine side effects, ciclesonide for outpatients, COVID-19 in newborns, portable air purifiers to reduce airborne transmission

Tocilizumab, vitamin D and COVID-19, bamlanivimab and etesevimab, Victoria’s second wave

Vaccine boosters, COVID-19-related death in vaccinated people, severe SARS-CoV-2 infection in children

Vaccine- and infection-induced immunity, delta community transmission among vaccinated and unvaccinated people, vaccines for under 12s

October

Sotrovimab, naproxen, waning immunity after vaccination with Comirnaty (Pfizer), the effect of vaccination on transmission

COVID-19 vaccines and children, mesenchymal stem cell treatment, TGA approval for Comirnaty (Pfizer) booster

Interferon-β, sensitivity of SARS-CoV-2 rapid antigen tests, the clinical care of children and adolescents with COVID-19

Waning immunity and booster strategies, rapid antigen tests, SARS-CoV-2 infection in school-aged children

Dexamethasone dosage, heterologous vaccination with Vaxzevria and Comirnaty, climatic signatures in COVID-19 waves

Untested infectious individuals in the spread of COVID-19, toxic effects from ivermectin use, WHO public health checklists for aviation and ports

Colchicine, acute respiratory distress syndrome and corticosteroids, sarilumab for COVID-19 pneumonia, COVID-19 infodemic management

COVID-19 vaccines against Delta, a post-exposure nasal spray, methods for short term forecasts of COVID-19 admissions

Glucocorticoids and viral clearance, haemoperfusion and blood purification strategies, reopening of international borders in Australia

Anakinra, screening in asymptomatic individuals, effect of vaccination on symptoms of post-acute COVID-19 syndrome

COVID-19 blockchain applications, post-acute sequelae of COVID-19, respiratory sub-phenotypes in COVID-19 patients with ARDS

Ruxolitinib, transmission in primary schools, heightened prenatal anxiety and depression during lockdown

Digital contact tracing, effect of mandatory COVID-19 certificates on vaccine uptake, WHO international travel public health measures

COVID-19 depressive and anxiety disorders, cannabidiol, mortality in people with mental disorders and intellectual disabilities during COVID-19

Immunomodulatory therapies in COVID-19, antiviral mouthwash, boosters, COVID-19 in children infected with the Delta variant

Bamlanivimab and etesevimab, maternal SARS-CoV-2 infection, waning of Comirnaty (Pfizer) vaccine protection, WHO guide on antigen tests

Tocilizumab, hospital prevalence as a mortality risk factor, antiplatelet therapy, WHO statement on booster doses

Antidiabetic agents and mortality risk, durability of immunity against reinfection, navigating from SARS-CoV-2 elimination to endemicity

Ventilator-associated pneumonia, behavioural interventions for physical distancing, vaccination and post-acute sequelae of COVID-19

Post-acute COVID-19 syndrome, pharmacological interventions, extracorporeal membrane oxygenation (ECMO) for COVID-19

September

Statins and COVID-19, news media coverage of public health and policy messages, serum magnesium levels in COVID-19

Tocilizumab, consent for vaccination for children, transmission of Delta in a partially vaccinated population, TGA news on self-tests

Antibody and cellular therapies in treating COVID-19, visual summary of guidelines for COVID-19 treatment, mRNA vaccines

Venous thromboembolism and severe COVID-19, waning immunity post-vaccination, mental health professionals encouraging vaccination

Multisystem inflammatory syndrome in adults, phase 3 trials of Spikevax and Novavax, REGEN-COV antibody combination to prevent COVID-19

Heparin, corticosteroids, favipiravir and arbidol, lung ultrasound for diagnosis

Saliva testing in primary care and for children, antivirals for COVID-19

ROX index as a predictor of high flow nasal cannula failure, risk prediction of COVID-19 related death and hospitalisation after vaccination

L-arginine treatment, menstrual changes after COVID-19 vaccination, considerations for booster vaccination

Prophylactic anticoagulation regimens, variant-modified mRNA vaccine boosters, resistance mutations to monoclonal antibodies

COVID-19 and the ageing immune system, self-sanitising masks, effectiveness and protection period of Pfizer, AstraZeneca and Moderna

Extended use of N95 masks, COVID-19 quarantine system failures, policy considerations for mandatory COVID-19 vaccination

Telecare case management, rapid antigen testing in children, the need for non-pharmaceutical interventions in long term care post-vaccination

High-intensity interval training after COVID-19 hospitalisation, impact of lockdown on key workers, vaccine passport

Mental and neurological disorders and COVID-19 risk, dynamics of antibody responses to Pfizer, COVID-19 lessons for pharmacists

Readmitted COVID-19 survivors, Pfizer in pregnancy, learning to live with COVID-19 in Australia

Late second dose or booster of AstraZeneca, baricitinib treatment, trends in emergency admissions for diabetic ketoacidosis

SARS-CoV-2 vaccination in immune-mediated inflammatory diseases, anakinra for early treatment, anti-SARS-CoV-2 seroprevalence in the US

Allergic reactions after Pfizer vaccination, casirivimab-imdevimab treatment, post vaccination SARS-CoV-2 infections

COVID-19 and immune-mediated inflammatory diseases, resurgence of SARS-CoV-2 infection in vaccinated healthcare workforce

Risk-factors for hospital readmission, Pfizer boosters, projected resurgence of COVID-19 in the US

Thrombocytopaenia and thromboembolism after vaccination, COVID-19 risk by occupation in healthcare workers

August

Household transmission, door-to-door COVID-19 testing program, one year outcomes post-hospitalisation for COVID-19, waning immunity

Hospitalisations and the Delta variant, vaccine effectiveness against Delta, TGA approval of Pfizer for 12+ years

Therapeutic anticoagulation with heparin, protecting long-term care facilities from COVID-19, negative seroconversion

Anticoagulation treatment, mental health and wellbeing of children and adolescents, emergency department design during COVID-19

COVID-19 transmission dynamics, SARS-CoV-2 reinfection, Delta variant transmission in schools

Hyperbaric oxygen therapy, real-world effectiveness of COVID-19 vaccines, TGA approval for sotrovimab

Sensitivity and specificity of rapid antigen tests, use of mobility data in local containment, COVID-19 and social relationships and health

School closures and COVID-19 transmission, convalescent plasma for high-risk outpatients, advance care planning during COVID-19

Insulin treatment and COVID-19, long-term sequelae of COVID-19 in people with airways disease, rapid antigen tests in nursing homes

Evidence base of COVID-19 guidelines, outcomes of breakthrough infections, COVID-19 in Australian children

Novel antigen rapid diagnostics for SARS-CoV-2, cannabidiol therapy for healthcare workers, remote patient monitoring

COVID-19 mortality in Europe, AstraZeneca and Pfizer homologous and heterologous immunisation, surgical leadership during COVID-19

Convalescent plasma, budesonide for COVID-19 in people at high risk, Moderna vaccine for adolescents

Electroconvulsive therapy, COVID-19 prevention and control measures in workplace settings, antigen testing

Long-term effects of COVID-19, anakinra, vaccines versus the Delta variant, TGA approval of Moderna vaccine

Pulmonary embolism in COVID-19 patients, BTK inhibitors, rapid antigen testing

Steroids for non-oxygen requiring patients, mandatory vaccinations for healthcare workers, breakthrough infections

Janus kinase inhibitors, therapeutic anticoagulation with heparin, monoclonal antibodies REGEN-COV for COVID-19 prevention

Isolation measures and people with dementia, convalescent plasma, global burden of acute myocardial injury associated with COVID-19

Behavioural nudges to increase COVID-19 vaccination, mass vaccination and lockdown requirements, interpreting time series of COVID-19 data

The safety profile of COVID-19 vaccines, asymptomatic COVID-19 infection, mandating vaccination for healthcare workers in the US

SARS-CoV-2 viral particles in the retina, self- reported memory problems post COVID-19, reactive vaccination approaches to outbreaks

July

Mood disorders and risk of COVID-19, tofacitinib for COVID-19 pneumonia, identifying and tracking SARS-CoV-2 variants

Predicting clinical deterioration, mental health disorders and mortality, rapid antigen tests, leadership of healthcare teams beyond COVID-19

Telerehabilitation for COVID-19 patients, post-acute COVID-19 syndrome, daily testing of schoolchildren

Enoxaparin in severe COVID-19, high-dose parenteral vitamin D3, improving healthcare delivery, reinfections

Temperature screening in COVID-19 triage, extended dosing of Pfizer vaccine, updated ATAGI advice

Dapagliflozin in patients with cardiometabolic risk factors, effectiveness of COVID-19 vaccines against the Delta variant

Solar UV-B/A radiation in inactivating SARS-CoV-2, viral infectivity 27 days after onset of COVID-19 symptoms, WHO weekly updates

COVID-19 vaccines, tocilizumab and systemic corticosteroids, frequency and phenotype of headache in COVID-19 patients

In-hospital COVID-19 complications, high-risk groups for severe COVID-19 in NSW, outcomes in vaccinated patients hospitalised with Delta variant

COVID-19 and mental disorders, learning disability, increased virulence of variants

Phase 3 trial of monoclonal antibodies, physician-delivered messages for COVID-19 behaviours, vaccination plus non-pharmaceutical interventions

SARS-CoV-2 antibodies in human milk, COVID-19 and people with spinal cord injury

Pfizer vaccine in pregnant women, mandating COVID-19 vaccines for healthcare workers, features of a Delta variant outbreak

Vaccine hesitancy, aerosol transmission and medical procedures, vaccine passports and health disparities

Phase 3 trial of CoronaVac, guidance for healthcare leaders, sensitivity of Delta variant to antibody neutralisation, COVID-19 endgame scenarios

Variants and vaccines, telehealth in Australian cardiology, COVID-19 outcomes in Sydney, asymptomatic rapid testing

WHO living guideline on therapeutics and COVID-19, IL-6 antagonists and mortality, biomarkers for asymptomatic infection

Meta-analysis of phase 3 trials of COVID-19 vaccines, caseload surge and COVID-19 survival, breakthrough infections

COVID-19 vaccine prioritisation, presymptomatic SARS-CoV-2 transmission, WHO guidance on international travel

Healthcare worker attitudes to COVID-19 vaccination, recovery time from COVID-19 in NSW, Lambda variant

Phase 3 trial of Novavax, age-related immune response to Pfizer vaccine, telenursing home care and COVID-19

Ivermectin treatment for COVID-19, reinfection and reactivation of SARS-CoV-2, CoronaVac vaccine in children

June

Parents’ consideration for child vaccination, extubation of ventilated COVID-19 patients, thrombosis after Moderna vaccination

COVID-19 in family clusters, interventions to increase personal protective behaviours, Pfizer booster in AstraZeneca-primed participants

Global seroprevalence of SARS-CoV-2 antibodies, Bell palsy, the impact of COVID-19 on life expectancy

Invasive mould disease in fatal COVID-19, variants and vaccines, genomic evolution of SARS-CoV-2 in an immunocompromised patient

Allergic reaction to SARS-CoV-2 vaccines, hospitalisation and the Alpha (B.1.1.7) variant, international comparison of containment strategies

Child mortality in England during COVID-19, persistent pulmonary disease, sustainable long-term infrastructure for COVID-19 vaccinations

Pneumothorax and COVID-19, AstraZeneca vaccine for people with HIV, transmissibility and global spead of SAR-CoV-2 variants

Mucormycosis, smoking and COVID-19 outcomes, ATAGI revised recommendations on AstraZeneca vaccine

Tofacitinib for COVID-19 pneumonia, control measures during vaccination rollout, COVID-19 systemic pathogenesis

Risk of hospital admission with Alpha (B.1.1.7) variant, nursing student acceptance of vaccination, the nursing profession post-COVID-19

Saliva or nasopharyngeal swabs for SARS-CoV-2 screening, renin-angiotensin-system inhibitors, social pharmacology

Obesity and COVID-19, repatriation in South Australia, managing vaccine-induced immune thrombosis and thrombocytopaenia in Australia

COVID-19 vaccine prioritisation, persistent SARS-CoV-2 infections, tracking SARS-CoV-2 variants

Pregnancy and neonatal outcomes, ‘COVID-19 conscience tracing’, nanotraps to prevent SARS-CoV-2 from infecting cells

Neonates with COVID-19 positive mothers, underlying medical conditions associated with severe COVID-19 in children, mask-related acne

Neurology and neuropsychiatry of COVID-19, ED presentations from Sydney quarantine hotels, COVID-19 swab-related skull injury

Efficacy of COVID-19 vaccines, SARS-CoV-2 detection dogs, ‘five Cs’ to tackle vaccine hesitancy

Co-infections and secondary infections, COVID-19 transmission in group living environments, an osteo-metabolic phenotype of COVID-19

SARS-CoV-2 variants and immune escape, WHO announces new names for variants of concern and interest

Vaccination and rheumatic disease, adipokines and obesity and severe COVID-19, breakthrough infections

Vaccine breakthrough infections, reinfections, seropositivity in Pfizer vaccinated cancer patients

May

Tracheostomy and COVID-19, Pfizer vaccine in adolescents, ATAGI update

Persistent COVID-19 symptoms, phase 3 trials of two inactivated SARS-CoV-2 vaccines, ocular findings in COVID-19 survivors

Corticosteroid therapy for COVID-19, infectiousness ‘through the infection course’, protecting Olympians from COVID-19

Weather and COVID-19, 6-month post diagnosis of paediatric inflammatory multisystem syndrome, controls for air travel into COVID-19 free countries

Post-acute COVID-19 syndrome, mixed prime-boost vaccines, vaccine effectiveness against variant B.1.617.2 (India)

Vaccine hesitancy practice pointer, excess deaths in 29 high-income countries, post-acute COVID-19

COVID-19 and liver abnormalities, prone positioning, PF4 immunoassays in vaccine-induced thrombotic thrombocytopenia

COVID-19 reinfection, virtual primary care, data concerns about the Sputnik vaccine

COVID-19 BMJ Best Practice guide, cytokine adsorption in ECMO patients, communicating about vaccine safety

JAK-inhibitors, lessons from the UK on vaccination, mixing vaccines for prime and boost doses

Mental health, Pfizer and AstraZeneca vaccine effectiveness in older adults, NHS England tackles surgical backlog

Written information to address vaccine hesitancy, complexity of COVID-19 vaccine patents, assessing physician resilience

Telehealth use in EDs, quality improvement during COVID-19, strategies to address vaccine hesitancy

COVID-19 and lung cancer, self-testing, precision medicine for COVID-19COVID-19 and lung cancer, self-testing, precision medicine for COVID-19

Vaccination strategies and herd immunity, drug treatments for COVID-19, SARS-CoV-2 transmission Q&A

Paediatric COVID-19, effective COVID-19 vaccine communication, aerosol generating procedures and transmission, infections post-Pfizer vaccination

Respiratory outcomes 3, 6 and 12 months post COVID-19 hospitalisation, Pfizer vaccination in Israel, vaccines in solid organ transplant recipients

UK guidance on preventing SARS-CoV-2 transmission, testing at scale, the SARS-CoV-2 ‘viral arms race’

Digital contact tracing, T-cell count as a prognostic marker, social distancing and airborne transmission, vaccine hesitancy

Tocilizumab in hospital patients, recovery strategies for cervical screening, a potential COVID-19 baby boom in Australia

The OxCOVID global database, BMI and COVID-19 severity, pulmonary fibrosis four months after severe COVID-19, the first billion vaccine doses

April

Pfizer vaccine in people with cancer, app for tracking post-vaccination side effects, vaccination and household transmission

COVID-19 related pressure injuries in patients and personnel, vaccine efficacy, social deprivation and mortality

Prophylaxis against COVID-19, immune-related manifestations of COVID-19, silent COVID-19 infections in children

COVID-19 risk with nebulisers, fewer hospitalisations and community cases in the UK, variant under investigation B.1.617 (India)

Stroke and SARS-CoV-2, post-acute sequelae of COVID-19 characterised, maternal and neonatal morbidity and mortality

Johnson & Johnson vaccine phase 3 trial, vaccine breakthrough infections with SARS-CoV-2 variants, India’s COVID-19 surge

Geographic differences in COVID-19 comorbidities, post-mortem after vaccination, COVID-19 in clinicians

Cardiac abnormalities in COVID-19 patients, monoclonal antibodies, the P1 (Brazil) variant and increased mortality in young people

COVID-19-funded research projects, reuse of N95 respirators, COVID-19 detection from breath and cough audio signals

Thoracic imaging for diagnosis, variants and vaccine efficacy, asymptomatic cases despite vaccination

Viral shedding and transmission, thrombotic thrombocytopaenia after vaccination

Interferon therapy, anticoagulation in COVID-19, autoimmune disease and post-acute COVID-19 syndrome

Contact tracing technologies, antibody response to Pfizer vaccine in dialysis patients, gut microbiota and COVID-19

Budesonide as a treatment for early COVID-19, cutaneous reactions to vaccines, medico-legal aspects of telehealth encounters

Post-vaccine thrombosis, drug treatments for COVID-19, vaccine passports

COVID-19 and obesity, cholesterol and triglyceride levels and severity, country-level risk and response to COVID-19

March

Reduced viral load post-Pfizer vaccine, SARS-CoV-2 infection and radiation therapy, US COVID-19 cases rise while vaccinations increase

The effect of COVID-19 on the brain, mask use, the Critical Health Resources Information System (CHRIS) in Australia’s intensive care units

Vaccine hesitancy in Australia, COVID-19 and population ageing, risk-based mammography

Asymptomatic COVID-19, vaccines in immunosuppressed patients, dynamics of antibody responses, communities of practice

Transmission in critical care, influenza and SARS-CoV-2 infectivity, routine testing strategies for airline travel

Post-acute sequelae of COVID-19 (PASC), new digital models of care in ophthalmology, key steps in the Australian vaccine program

Neutralising antibodies after infection and vaccination, living with children and the risk of COVID-19, vaccine second-dose completion in the US

Durability of neutralising antibodies, malnutrition risk with CPAP, has COVID-19 peaked?

AstraZeneca vaccine efficacy against B.1.351 (South Africa) variant, ED presentations from Sydney quarantine hotels, reinfection rates

COVID-19 and stroke services in Australia, COVID-19 and artificial intelligence, Rehabilitation Research Framework for COVID-19 patients

Mortality and the UK / Kent variant, a ‘Green Pass’ post-vaccination proposal in Israel, timeline of immunological insights about COVID-19

Serial interval and incubation period, surgery following COVID-19 infection, the impact of the vaccination program in Israel

Quality of COVID-19 clinical guidelines, phase 1 trial of Johnson & Johnson vaccine, COVID-19 and seasonal influenza comparisons

Heightened risk of mortality with the UK/Kent variant, COVID-19 and liver disease, virtual health care for community management in Australia

Phase 2 trial of Covaxin, serosurveys for public health decision-making, Pfizer vaccine effectiveness

GP experience of COVID-19 in Australia, risks of delaying second vaccine dose, COVID-19 symptom persistence for up to 10 months

Different country responses to COVID-19, digital inequities in supporting young indigenous Australians

Mobile robotics for patient evaluation, SARS-CoV-2 on ocular surfaces, antivaccination infodemic, optimal use of different vaccines

Reprocessing N95 respirators, satisfaction with telehealth, approaches to promote adherence to physical distancing

Incubation period, lateral flow assays, effectiveness of Pfizer and AstraZeneca vaccines in England

Mutation D614G and enhanced transmission, patients with cancer and COVID-19, the Johnson & Johnson vaccine, phase 2 trial of Novavax

Obesity and vaccine efficacy, backward contact tracing, indirect impacts of COVID-19 on Aboriginal communities

Psychological illness after COVID-19, the RECOVERY platform’s dexamethasone trial, effectiveness of Pfizer vaccine

February

The downsides of face masks, seropositivity and future infection risk, immune escape of variants

Arterial and venous thromboembolism, a multiple site outbreak in Sydney, spread and dominance of B.1.1.7 (UK / Kent) variant across Europe

Moderna vaccine and the South African variant of concern, uncertainty in modelling, insights from behavioural economics

AstraZeneca single dose efficacy at 90 days, rate reduction in SARS-CoV-2 infection and COVID-19 post Pfizer vaccination, super-spreaders

Years of life lost to COVID-19, payments for vaccination, news media and risk narratives, vaccine ‘real world’ effectiveness

Convalescent plasma therapy, vitamin D3 treatment, neutralising activity of Moderna and Pfizer vaccines against variants of concern

Paediatric COVID-19, vaccine side effects, a potential endemic future

Diagnostic tests, variants, effectiveness of Pfizer vaccine, a decision framework to guide social and movement measures

Zinc and ascorbic acid supplements do not affect symptoms, prophylactic anticoagulation, single dose of Pfizer vaccine in Israel

Face mask efficacy, COVID-19 detection by dogs, the pandemic’s first year

SARS-CoV-2 genome and antibodies in breastmilk, transmission rates in specific settings, Moderna and Pfizer vaccine efficacy against variants

Asymptomatic SARS-CoV-2 carriers, update on remdesivir, Pfizer vaccine response in recovered COVID-19 patients

Prevention of SARS-CoV-2 transmission in hospital air, preoperative assessment decisions, viral load post-vaccination

PPE and healthcare workers, COVID-19 incubation period, multiple studies on vaccines and variants of concern

Statin use, phase 1/2 trial for CoronaVac, nasopharyngeal decolonisation

Prediction models for diagnosis and prognosis, the RECOVERY trial and azithromycin, rapid testing technologies

Sputnik vaccine phase 3 trial, mortality in intensive care, SARS-CoV-2 persistence post-recovery

Post-vaccination COVID-19 symptoms in Israel, antibody responses to single dose vaccination in previously infected people

Face masks in the community, COVID-19 recurrence, point-of-care testing

Demand and occupancy in Australian EDs during the pandemic, social distancing and vaccinations, Novavax phase 3 trials

January

Pfizer vaccine neutralisation of new variants, ivermectin, effective communication strategies

Vaccines for patients with IBD, diabetes and for pregnant women, future epidemiology and clinical trial research, early data on UK vaccine rollout

Asymptomatic infections, guidelines for long term effects of COVID-19, global preparedness and pandemic warning systems

Vaccine prioritisation and commentary, monoclonal antibodies (-mabs), non-pharmaceutical interventions

New evidence on variants, remote vital sign monitoring, COVID-19 deniers

Pandemic rostering in Victorian EDs, COVID-19 reinfection, UK guidance on vaccines for patients on anti-cancer therapy

Vaccines and allergies, antibody responses, in-flight transmission of SARS-CoV-2, COVID-19 guidance for Aboriginal people

Saliva versus nasopharyngeal swabs, vaccine schedule and adverse events, post-acute COVID-19

Vaccines

2020

December

Cancer surgery delays, pulmonary embolism and DVT, Guillain Barré Syndrome, COVID-19 mortality in US adults

Household transmission, government interventions, vaccine promotion

Allocation of mechanical ventilators, gene editing, fever monitoring using wearables, vaccine approvals

False-negative COVID-19 tests, vaccine trials, artificial intelligence, framework for surge planning

Primary care responses to COVID-19, SARS-CoV-2-specific immune memory, equitable access to vaccines, mass screening programs

Age-specific COVID-19 fatality rates, emergency use designation for vaccines, ethics of “safer infection sites”

Oxford-AstraZeneca vaccine, face masks and social distancing, rapid and mass testing

Mental health and lockdown, integrated care for long COVID, experience of a vaccine trial, OECD and NHS guidance

Healthcare worker mortality, paediatric perforated appendicitis, mortality risk prediction using vital signs, iatrogenic skull base injury

Reopening schools, telehealth implementation, health consequences of COVID-19, intended vaccine uptake

Long-distance droplet transmission, COVID-19 data sharing, vaccines

Pre-existing mental illness and pandemics, rehabilitation for critically ill patients with COVID-19, WHO guidance on mask use

Outdoor transmission of SARS-CoV-2, UK vaccination strategy, patents and COVID-19 vaccines

Impact of COVID-19 on cancer survivors, respirator reuse, international alcohol consumption, influenza in Australia

November

Recurrent positivity, impact on cornea donation, vaccine cost effectiveness

Convalescent plasma, database on government responses to COVID-19, science communication

Economic evaluation, surface contamination, SARS-CoV-2 reinfection

COVID-19 emergency and palliative care, the NSW Critical Intelligence Unit, vaccine allocation

Surgical practice, effects of intravenous immunoglobulin, body mass index (BMI) and COVID-19, vaccine implementation

Preparing for resurgence, antibiotic use in COVID-19, mass screening, behavioural insights

Mask effectiveness, pre-symptomatic detection using smartwatch data

Management of obstetric emergencies, suicide in Queensland, immune suppression, acute pancreatitis

Effectiveness of non-pharmaceutical interventions, maternal mental health, COVID-19 testing in the UK

Randomised trials, politicisation of science, superspreading

Reproductive number (R0), low dose far-UVC lighting, collider bias, suicide trends

Sampling methods, Sydney seroprevalence, airborne dispersal in hospitals

COVID-19 and psychiatric disorder, neonatal COVID-19, seven critical lessons, mink farms

Real-time localised risk information, human challenge studies, Pfizer vaccine

Surgical masks versus respirators, household transmission, bus contamination

COVID-19 tests, remdesivir, impact on notifiable diseases

Draping in surgical procedures, chatbots for COVID-19 screening, cardiac rehabilitation, supporting resilience in frontline staff

Recurrence of COVID-19, venous thromboembolism, fatality rates across countries, WHO insights

Gastrointestinal and liver injury, elective surgery, mortality and immunity patterns, science denial and conspiracy theories

Out of hospital cardiac arrest, organotropism, neurological and rheumatic manifestions, near-source wastewater tracking

Vaccine efficacy, case vignettes, super-spreaders and super-susceptibles

October

Ischaemic stroke, neutralising antibodies, second wave, vaccines

Airborne transmission, PPE in the Emergency Department, frailty

Transmission, deferred care, gestational diabetes, junior doctors

Convalescent plasma ineffective, ventilation management, decreases in organ donation as an indirect impact

Lifting non-pharmaceutical interventions, vaccines, engines of spread, incubation period

Child and family outcomes post-pandemics, ICU contamination, epidemic suppression and vaccine development

Neurological manifestations, postoperative mortality, congregate living settings, viral shedding

Acknowledging uncertainty, scientific divisions, herd immunity, ultraviolet-B radiation, vaccines

Cytokine elevation, virtual cancer genetic services, comparative evidence on drug treatments, immunity passports

Re-positive patients, sensible medicine, COVID-19 ‘circuit breaks’

All-cause mortality, orthopaedic trauma at RNSH, COVID-19 vaccines

Takotsubo syndrome, arrhythmias in COVID-19, reinfection

Aerosol-generating procedures, vertical transmission during pregnancy, pandemic staffing, excess deaths

Cutaneous COVID-19, regional strategies, complexity science, post-traumatic growth

Psychological impact of isolation, portable negative pressure innovation, sewage surveillance

Aerosols and extubation, severe paediatric ketoacidosis, public health research needs

Acute kidney injury, super-spreaders, communicating risk

Prophylactic anticoagulants, in-hospital cardiac arrest, changes in alcohol consumption, social license and big data

Research letters on aortic valve replacement, in-hospital cardiac arrests, older people in vaccine trials

Hand sanitisers, stroke, flight-associated transmission, off-label use of disinfectants

September

Ventilation, general practice, health system preparedness, social distancing and border restrictions

E-mental health solutions, Favipiravir, poor appetite and overeating during COVID-19, ethics of health worker wellbeing

Easing restrictions, efficacy of masks, patient heterogeneity, herd immunity, telerehabilitation

Pulmonary embolism, politicisation of mask use, animal models for testing, TGA regulation of PPE

ECMO telerounding, point-of-care tests, digital health

Cocooning vulnerable populations, cancer care in Victoria, community testing, decreased ED wait times

Temperature and humidity, methylprednisolone, in-flight transmission, viral loads

COVID-19 transmission, antiviral therapeutics, intimate partner violence, pre-existing immunity, clusters and super-spreading

Diabetes, cultural norms, voice assistants, vaccine update

Universal screening, guideline development, intention to vaccinate

Effect of quarantine and social restrictions, duration of COVID-19 immunity, targeted testing

Drug treatments, adaptive immunity, influenza and COVID-19, speech-generated transmission

Alternative service delivery, risk communication, vaccine confidence, outdoor transmission

Trauma admissions in Westmead Hospital, innate immunity, herd immunity, vaccines

Antibody testing, reduced C.difficile infections, equitable access to vaccines, “variolation”

COVID-19 indirect impact, role of centres of government, non-communicable diseases

Modelling transmission in Victoria, visual summary of drug treatments, corticosteroids, vaccines, healthcare simulation models

Systemic corticosteroids, non-communicable diseases, asymptomatic transmission

Maternal and perinatal outcomes, contact tracing, oxygen targets for mechanical ventilation

Viral transmission, equity, managing uncertainty, mobility data

Medical education, localised lockdowns, long-term care services

Oxygen therapy and infection risk, triage, immune response

August

Post-pandemic clinician mental health, air travel, international data descriptors, mask use, transmission in schools

High flow nasal cannula, diabetes, COVID-19 reinfection, physical distancing, data visualisation

Psychological morbidities, lung transplantation, machine learning, COVID-19 heroes

Haematological and immunological markers, vulnerable populations, aerosol transmission, home care guidelines

Disease management, clinical trials, enhancing value post-COVID-19, fit checking masks

Powered air purifying respirators (PAPR), serological testing, psychiatric syndromes

Testing strategies, mental health, fast‐track care for diabetic foot ulcers

Radiation fractionation, telemedicine in cardiovascular surgery, Auxora randomised controlled trial, advance care planning

Mental health, pulmonary cavitation, long-term care facilities

Endoscopy services, teledentistry, drug repurposing

Risk factors, ECMO, haemodynamic monitoring, diabetes

Convalescent plasma, obesity, precision public health

Tracking the spread, digital public health, post-acute COVID-19, telmisartan

Antiviral agents, telehealth, palliative care, translated COVID-19 resources

Health economics and trade-offs, variation in management of severe COVID-19, WHO indicators

Children and COVID-19, recovery from severe disease, responses to domestic violence, elimination strategies

Immunotherapies, medical waste, healthcare worker wellbeing

ECMO, reopening schools, healthcare workers, WHO timeline

Cancer immunotherapy, oral health services and long-term respiratory complications

Vaccine evaluation, living review of drug treatments, rehabilitation, cellular immune response, modelling hospital resource needs

Thrombolysis for STEMI, Proton Pump Inhibitors, PCR positivity in healthcare workers

July

School closures, reflections from American CEOs, wastewater surveillance

Stroke and preceding infection, behavioural science, travel restrictions

Aboriginal people at risk, pregnancy, planned care

Coagulopathy, aerosols, contact tracing, mental health

Daily Evidence Digest

Health system and quality perspectives, vulnerable populations

Impact of delays in cancer referral and diagnosis, national preparedness, tailoring contact, treatment and support for ethnic groups

Vaccine trials, patient-reported data, emergency preparedness

Risk tool, Victoria lockdown, disease recurrence, defining COVID-19 deaths

Physical distancing, contact tracing, inequalities, screening and risk

Diagnostic tests, impacts on healthcare workers, resuming elective surgery

Viral transmission, vaccine development, probiotics, leadership, triage

Acute kidney injury, convalescent plasma, College updates

Extra‐pulmonary symptoms, gendered attitudes, persistence of antibodies

Surgical workflow, infection prevention precautions and global health law

Reshaping Australia’s health system, RECOVERY trial and rehabilitation post COVID-19

Comparative clinical studies, cancer care, and disparities

Lung abnormalities, immunology, cardiac tele-rehabilitation

Digital pathology, fomites, health literacy, mobile-health

Serological tests, excess deaths, cancer care and surgical recovery

Frailty, intensive care, social distancing, and telehealth

Global perspectives, PPE training, stroke, podcasts

Loneliness, risk communication, screening pre-surgery

June

Infection control, high flow nasal cannulae, Twitter, influenza

Antibody tests, PPE, resuscitation, surveillance

Telehealth, comorbidities, depression and anxiety

Telehealth, comorbidities, depression and anxiety

Healthcare reform, lessons and innovations and research priorities

Artificial intelligence, masks, ethical dilemmas and exit strategies

Home pulse oximetry, transmission dynamics, and virtual hospitals

Genome, telemedicine, ethics, dexamethasone trial

Environmental contamination, vaccinations during COVID-19, research

Urology, diabetes, rheumatic disease, stroke, occupational health

Ethics, viral transmission, equity and ‘lockdown’

Telehealth, maternal complications and extra-pulmonary presentations

Mental health, drug repositioning, phone apps and homelessness

Antivirals, long-term intubation, bacterial co-infection

Testing, diabetes, ethics of drug repurposing, Google search trends, extended use and reuse of facemasks

Non-invasive and extracorporeal oxygenation, mask reuse, adapting care

Aerosol generating procedures, challenges for EDs, myocardial injury

Physical distancing, face masks, heart failure, research quality

Hypertension, mental health, staff wellness, system responses

Cancer, clinical trials, telehealth, and managing teamwork

May

Stroke, ‘outbreak rostering’, viewpoints on policy and clinical research

Cardiac imaging, frailty, 3D printed swabs and rural emergency care toolkit

Ventilation techniques, medical education, neurosurgery, smoking and nicotine

Cardiovascular disease, risk factors, and convalescent plasma

Daily evidence digest

Nutrition, conspiracy theories, supply chain management, cancer care

Clinical course, thrombotic risk, evidence-based virtual care

Non-COVID ED presentations, disability rights, virtual care in NICU and obstetrics, cancer

Safety of corticosteroids, infection control measures, climate and mortality risk

ICU modelling, nutritional risk, spinal cord injury, diabetes

Call for robust trials, convalescent plasma, screening, mortality

Steroids, triage algorithm, ventilator allocation, prognostic tool

Research informed strategy, equity, post infection immunity, symptom tracking

Triple combination treatment, NSW response, non-communicable disease

Screening and diagnosis, paediatrics, post-COVID strategies

Anticoagulation, community-based healthcare, and acute kidney injury

International lessons, emergency departments, acute stoke management

Telemedicine, ethics, equity and NATSIHWA collaboration toolkit

Drug treatments, restarting surgeries, and populations-in-focus

First Nations people, immunosuppressive therapies, stroke, remdesivir

April

Protective immunity, immunosuppressed patients, pathophysiology

Pregnancy, policy comparisons, influenza during COVID-19

Diabetes, kidney transplants, opioid dependence, COVIDSafe

Screening healthcare workers, nutrition and food safety, webinars

Modelling, epidemiology, suicide risk, preventing hospital admissions

Endotheliitis, ventilator demand, testing, infection control, the path forward

Views from oncologists, masks, wellbeing, exit strategies

Cohort study, telehealth, oxygen therapy, protective gowns, WHO guidance

PPE, updates from WHO, health messaging for Aboriginal communities

Emerging from lockdown, testing, treatments, and nosocomial infection

Respiratory and diabetes guidance, infection control and underreporting

Second-wave transmission, managing diabetes, pain

Diagnostic testing, addressing ICU challenges, correctional facilities

Virology, temporary hospitals, reorganisation of care, leadership

ACE-I/ARB continued use, CVD advice, burns, diabetes

NICE Guideline, mental health, telehealth, ethics

New guidance on emergency medicine, re-use of face-piece respirators, NSAIDs, podcasts, tiered staffing

New guidance for Aboriginal people, GP telehealth, surge capacity, model-based analysis of severity, vulnerable workforce

CPAP, neurosurgery, occupational medicine, surgery, gastroenterology, maintaining essential services, spirometry

March

New guidance, cardiac patients, rapid EBM reviews, ED, telehealth

Community health workers, elective surgery, hospital capacity, telehealth, de-isolation, modelling, clinical trials

Ethics, remote assessment, use of mechanical ventilation in UK, management strategies in China

Evidence Checks

2022

Epidemiology, Transmission, Virology

Community transmission and hospital infection, stages of pandemic, immunity, and vaccination.

In brief - Omicron (BA.2 sub-lineage)

In brief - Mask type for COVID-19 positive wearer

In brief - Surgical masks, eye protection and PPE guidance

In brief - Paediatrics and COVID-19 – reporting, rates and differences

Symptoms, Diagnosis and Treatment

Pathogenesis, asymptomatic, pre-symptomatic, severity, seroconversion, drugs, and recovery.

In brief - Budesonide and aspirin for pregnant women with COVID-19

In brief - Surgery post COVID-19

In brief - Disease modifying treatments for COVID-19 in children

In brief - Omicron – symptoms and hospitalised patients

System Capacity and Planning

Infrastructure, hospital capacity, human resources, supplies, measurement and monitoring, surveillance, prediction, evaluation, and post-pandemic.

In brief - COVID-19 pandemic and wellbeing of critical care and other healthcare workers

In brief - Hospital visitor policies

In brief - Incidental COVID-19

2021

Epidemiology, Transmission, Virology

Community transmission and hospital infection, stages of pandemic, immunity, and vaccination.

In brief - Omicron (B.1.1.529)

In brief - Paediatric respiratory infections after lockdown & school reopening

In brief - Hospitalisation and ICU admission – relative risk for vaccinated versus unvaccinated people

In brief - Face masks and COVID-19 transmission in the community

In brief - De-isolation and risk of transmission

In brief - COVID-19 vaccine booster shots

Therapeutic sessions and personal protective equipment

In brief - Period of isolation relevant to vaccination status

In brief - Children and COVID-19 outcomes

COVID-19 vaccines in Australia

In brief - COVID-19 vaccines and fertility

In brief - Ocular transmission

In brief - Ocular transmission

Steroid use post COVID-19 vaccination

In brief - COVID-19 vaccines in Australia – AstraZeneca and Pfizer

In brief - Delta variant

COVID-19 vaccine and elective surgery

Immunocompromised patients and COVID-19 vaccines

Endemicity of SARS-CoV-2

SARS-CoV-2 variants

Emerging evidence about COVID-19 vaccines

Symptoms, Diagnosis and Treatment

Pathogenesis, asymptomatic, pre-symptomatic, severity, seroconversion, drugs, and recovery.

In brief - Post-acute sequelae of COVID-19

Sotrovimab – in brief

In brief - Respiratory therapies and COVID-19

Foetal and neonatal outcomes of COVID-19 in pregnancy

In brief - Molnupiravir

Initiation of remdesivir treatment for COVID-19

In brief - Treatment for COVID-19 in pregnant people

COVID-19 and maternity and newborn communities of practice

Continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BiPAP)

Evidence on AstraZeneca vaccine rollout

COVID-19 rapid testing

Sample types and collection for COVID-19 diagnostic tests

Clinical Models of Care

Triage, virtual care, hospitalisation, palliative care, temporary hospitals, infection control, and ethics.

Acute mental health inpatient unit risk mitigation and models

Post-acute and subacute COVID-19 care

In brief - Oxygen saturation monitors/pulse oximeters for COVID-19

Organisation of emergency departments during COVID-19

Triage tools for ICU admission during COVID-19

Thermal imaging for detection of fever

Mental health models to support children and young people

System Capacity and Planning

Infrastructure, hospital capacity, human resources, supplies, measurement and monitoring, surveillance, prediction, evaluation, and post-pandemic.

In brief - Test, trace, isolate and quarantine

In brief - Public health measures and COVID-19 vaccine rollout

Workforce reconfiguration

In brief - Furloughing staff following exposure to COVID-19

Extended use or reuse of personal protective equipment

In brief - Ethics and duties of treating COVID-19 patients

In brief - Rapid antigen testing

Quarantine measures

COVID-19 pre-peer review articles

2020

Epidemiology, Transmission, Virology

Community transmission and hospital infection, stages of pandemic, immunity, and vaccination.

Deployment and vaccination plan for COVID-19

In brief - Fomite transmission and deep cleaning

High-risk settings for transmission of COVID-19

Infection control recommendations in the emergency department according to local transmission risk

Respirator fit testing

Second spike in COVID-19 cases

Cardiopulmonary resuscitation (CPR)

COVID-19 infection and transmission in domestic animals

Surgical masks and oxygen therapy

Face masks and COVID-19 transmission in the community

Cardiac stress testing

COVID-19 transmission risk on aircraft

Hydrotherapy and COVID-19

Nosocomial COVID-19 infections

COVID-19 infectivity and transmission in children

Sanitising and covering large medical imaging equipment

Modes of transmission for COVID-19

Winter and COVID-19 transmission Rapid

The effect of COVID-19 on healthcare workforce - infections

Symptomatology and Treatment

Pathogenesis, asymptomatic, pre-symptomatic, severity, seroconversion, drugs, and recovery.

Ivermectin and COVID-19

Aged care facilities and COVID-19

Medium- and long-term health sequelae of COVID-19

Vascular dysfunction and COVID-19

Risks associated with surgery in people with COVID-19

Computed tomography use during the COVID-19 pandemic

Large vessel occlusion strokes in COVID-19 patients

Immunosuppression and COVID-19

Renal replacement therapies for COVID-19 positive patients in ICU

NIPPV and requirements

Fibrinolysis and PCI for STEMI

Inpatient management of COVID-19

Neonates and COVID-19

Non-invasive ventilation and inspiratory muscle training for spinal cord injury patients

COVID-19 testing before surgery

Continuous Positive Airway Pressure (CPAP) machines

Spirometry and transmission risk

Prone position for COVID-19 patients

Laparoscopy during COVID-19

Drug therapies and COVID-19

Medical college advice on COVID-19

Select international medical college advice on COVID-19

Surgical specialties advice on COVID-19

ECMO and COVID-19

Clinical Models of Care

Triage, virtual care, hospitalisation, palliative care, temporary hospitals, infection control, and ethics.

Models of emergency department mental health care

Conducting virtual respiratory assessments and monitoring via telehealth

Preserving consumer and patient partnership during COVID-19

Virtual care and telehealth for specific conditions

Reducing adverse impacts of people with a lived experience of severe mental health issues during COVID-19

Assessment and management of COVID-19 patients in the emergency department (ED)

Homelessness and COVID-19

Telehealth and COVID-19

Pulmonary rehabilitation and COVID-19

Diabetes care during COVID-19

Rehabilitation needs of post-acute COVID-19 patients

Intubation in the emergency department during COVID-19

Management of acute behavioural disturbance and COVID-19

Validated tools to diagnose respiratory illness via telehealth

Triage tools for ICU admission during COVID-19

Palliative care and COVID-19

Telemedicine in intensive care units – An evidence check

System Capacity and Planning

Infrastructure, hospital capacity, human resources, supplies, measurement and monitoring, surveillance, prediction, evaluation, and post-pandemic.

Routine border screening

Wastewater surveillance for COVID-19

Elective surgical procedures, non-surgical alternatives and shared decision-making

Waste from personal protective equipment

Resuming elective surgery – Volume-outcome relationships in surgery

Extended use or reuse of personal protective equipment

Resuming elective surgery – the evidence for prehabilitation

Resuming elective surgery - Post-surgery innovations

Resuming elective surgery – productivity and efficiency approaches

Resuming elective surgery - Post-surgery innovations: enhanced recovery after surgery, early mobilisation and discharge

Resuming elective surgery – low-value care

Resuming elective surgery

Extended use or reuse of personal protective equipment

The impact of COVID-19 on clinical education and training

Workforce reconfiguration

Guidance and underlying evidence about personal protective equipment (PPE) use during COVID-19

Domestic and family violence and COVID-19

Temporary shared accommodation (boarding houses, backpacker accommodation and hostels)

Mental health of healthcare workers

Tools to support communication between patients and families

Dedicated or temporary COVID-19 healthcare facilities

Thermal imaging for detection of fever

Personal protective equipment and intrapartum care for low risk women

Ventilation use for COVID-19 patients

Models for redeploying staff